Projects

FRETイメージングによる神経突起伸展の分子メカニズムの解明(～2011)

Goto A, Hoshino M, Matsuda M, Nakamura T. Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells.　
Mol Biol Cell. 22:1780-90, 2011.

FRETイメージングによる腸管神経前駆細胞の移動の分子メカニズムの解明(～2013)

Goto A, Sumiyama K, Kamioka Y, Nakasyo E, Ito K, Iwasaki M, Enomoto H, Matsuda M.
GDNF and Endothelin 3 regulate migration of enteric neural crest-derived cells via protein kinase A and Rac1. J Neurosci. 33 (11): 4901-4912, 2013.

報酬、忌避応答や性行動中の線条体におけるキナーゼ活性のリアルタイム観察 (～2015)

Goto A, Nakahara I, Yamaguchi T, Kamioka Y, Sumiyama K, Matsuda M, Nakanishi S, and Funabiki K.
Circuit-dependent striatal PKA and ERK signalings underlie behavioral shift in Male Mating Reaction.　
Proc Natl Acad Sci U S A. 112 (21):6718-23, 2015.

新たな光遺伝学による記憶の長期保存の細胞機構の解析 (～2021)

Goto A, Bota A, Miya K, Wang J, Tsukamoto S, Jiang X, Hirai D, Murayama M, Matsuda T, McHugh T, Nagai T, and Hayashi Y.
Stepwise synaptic plasticity events drive the early phase of memory consolidation.
Science 374(6569) 857-863, 2021.