Projects

Analysis of cellular mechanisms of long-term storage of memory by new optogenetics (～2021)

Goto A, Bota A, Miya K, Wang J, Tsukamoto S, Jiang X, Hirai D, Murayama M, Matsuda T, McHugh T, Nagai T, and Hayashi Y.
Stepwise synaptic plasticity events drive the early phase of memory consolidation.
Science 374(6569) 857-863, 2021.

Molecular mechanisms of enteric neural progenitor cell migration revealed by FRET imaging. (～2013)

Goto A, Sumiyama K, Kamioka Y, Nakasyo E, Ito K, Iwasaki M, Enomoto H, Matsuda M.
GDNF and Endothelin 3 regulate migration of enteric neural crest-derived cells via protein kinase A and Rac1. J Neurosci. 33 (11): 4901-4912, 2013.

Real-time observation of kinase activity in striatum during reward and avoidance responses and sexual behavior. (～2015)

Goto A, Nakahara I, Yamaguchi T, Kamioka Y, Sumiyama K, Matsuda M, Nakanishi S, and Funabiki K.
Circuit-dependent striatal PKA and ERK signalings underlie behavioral shift in Male Mating Reaction.　
Proc Natl Acad Sci U S A. 112 (21):6718-23, 2015.

Study of molecular mechanisms of neurite outgrowth using FRET imaging. (～2011)

Goto A, Hoshino M, Matsuda M, Nakamura T. Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells.　
Mol Biol Cell. 22:1780-90, 2011.